Trifluoroacetic acid → Benzyl ethyl(piperidin-4-yl)carbamate trifluoroacetate

HRID 1193414ノート

反応式

HRID 1193414 の反応式
[C:1]([OH:7])([C:3]([F:6])([F:5])[F:4])=[O:2].[CH2:8]([O:15][C:16]([N:18]([CH2:32][CH3:33])[CH:19]1[CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]1)=[O:17])[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1>C(Cl)Cl>[F:4][C:3]([F:6])([F:5])[C:1]([OH:7])=[O:2].[CH2:32]([N:18]([CH:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1)[C:16](=[O:17])[O:15][CH2:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)[CH3:33]

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 18677722Tert-butyl 4-(((benzyloxy)carbonyl)(ethyl)amino)piperidine-1-carboxylate

生成物 1

HCID 66799319Benzyl ethyl(piperidin-4-yl)carbamate trifluoroacetate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

TFA (2.5 ml) was added at 0° C. to a solution of tert-butyl 4-((benzyloxycarbonyl)(ethyl)-amino)piperidine-1-carboxylate (1.5 g, 414 mmol, 1.0 eq) in DCM (10 ml) and the mixture was stirred for 2 hours at RT. After monitoring by TLC, the reaction mixture was concentrated under reduced pressure and dried. The crude product was used in the next stage without being purified further.

後処理

  1. concentrationthe reaction mixture was concentrated under reduced pressure
  2. customdried
  3. customwithout being purified further

出典と根拠

ORDレコード
ord-64797714bca04b9494c3d5d12c02f32f
出典データセット
uspto-grants-2014_03
特許番号
US08680159B2

反応ノート

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