Formaldehyde → 3-(Anilinomethyl)-1,3-benzothiazole-2(3H)-thione

HRID 1193462ノート

反応式

HRID 1193462 の反応式
[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[SH:8][C:9]1[S:10][C:11]2[CH:17]=[CH:16][CH:15]=[CH:14][C:12]=2[N:13]=1.[CH2:18]=O>C(O)C>[C:2]1([NH:1][CH2:18][N:13]2[C:12]3[CH:14]=[CH:15][CH:16]=[CH:17][C:11]=3[S:10][C:9]2=[S:8])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

5

反応物 3

HCID 712FormaldehydeHCID 6115AnilineHCID 178418395HCID 178418395、化合物

生成物 1

HCID 2204713-(Anilinomethyl)-1,3-benzothiazole-2(3H)-thione収率 86.3%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

With stirring, 18.63 g (0.2 mole) of aniline are added to a suspension of 33.45 g (0.2 mole) of 2-mercaptobenzothiazole in 120 ml of ethanol, the temperature rising to 30° C. Then 16.4 g (0.2 mole) of 37% aqueous formaldehyde solution are added and stirring is continued for 30 minutes. The precipitate is isolated by filtration and washed with cold ethanol and hexane, affording 47 g of 3-(phenylaminomethyl)benzothiazoline-2-thione which melts at 102°-103° C.

後処理

  1. customrising to 30° C
  2. stirringstirring
  3. customThe precipitate is isolated by filtration
  4. washwashed with cold ethanol and hexane

出典と根拠

ORDレコード
ord-5cda1fd85c8a4ea39d099d74b891d331
出典データセット
uspto-grants-1989_03
特許番号
US04810399

反応ノート

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