Diethyl Ether → 3-(3,5-Difluorophenyl)propyl Isothiocyanate
反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][CH2:11][NH2:12])[CH:5]=[C:6]([F:8])[CH:7]=1.C(N(CC)CC)C.[C:20](Cl)(Cl)=[S:21].C(OCC)C>O1CCCC1>[F:1][C:2]1[CH:3]=[C:4]([CH2:9][CH2:10][CH2:11][N:12]=[C:20]=[S:21])[CH:5]=[C:6]([F:8])[CH:7]=1参加物
6
実験手順
A solution of 3-(3,5-difluorophenyl)propylamine (0.0327 mol) and triethylamine (0.072 mol) in tetrahydrofuran (20 ml) was added dropwise to a solution of thiophosgene (0.0392 mol) in tetrahydrofuran at 0°. The reaction was stirred 2 hours at room temperature then ethyl ether was added and the mixture filtered. The filtrate was concentrated and distilled (Kugelrohr) to yield 3.8 g (55%) of a yellow oil.
後処理
- filtrationthe mixture filtered
- concentrationThe filtrate was concentrated
- distillationdistilled (Kugelrohr)
出典と根拠
- ORDレコード
- ord-2b91444dcacf44ffb40a8e8ff61acae6
- 出典データセット
- uspto-grants-1989_03
- 特許番号
- US04810811
反応ノート
読み込み中…