Sodium Hydroxide → HCID 178433474、化合物

HRID 1193781ノート

反応式

HRID 1193781 の反応式
[OH-].[Na+].[OH:3][C:4]1[N:12]=[C:11]([CH3:13])[CH:10]=[CH:9][C:5]=1[C:6]([OH:8])=[O:7].[Cl:14][O-].[Na+]>O>[Cl:14][C:10]1[CH:9]=[C:5]([C:6]([OH:8])=[O:7])[C:4]([OH:3])=[N:12][C:11]=1[CH3:13]

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 23665760Sodium HypochloriteHCID 178425908HCID 178425908、化合物

生成物 1

HCID 178433474HCID 178433474、化合物

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a solution of 15.7 g of 50% sodium hydroxide and 18.2 ml of water was added 10 g (0.065 mole) of 2-hydroxy-6-methylnicotinic acid. When the acid had dissolved, 200 ml of 5.25% aqueous sodium hypochlorite was added rapidly through a dropping funnel. The temperature was not moderated (slight exotherm did occur). The entire mixture was stirred at room temperature for 18 hr. The reaction mixture was then filtered and acidified with concentrated hydrochloric acid. The precipitate was recrystallized from isopropyl alcohol/ethereal to give ~6 g of analytically pure crystals, m.p. 291°-94° C.

後処理

  1. dissolutionWhen the acid had dissolved
  2. filtrationThe reaction mixture was then filtered
  3. customThe precipitate was recrystallized from isopropyl alcohol/ethereal
  4. customto give ~6 g of analytically pure crystals, m.p. 291°-94° C.

出典と根拠

ORDレコード
ord-f9fdd29238874400a63541dbce93e215
出典データセット
uspto-grants-1989_03
特許番号
US04810795

反応ノート

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