Propargyl alcohol → isopropyl 2-chloro-4-fluoro-5-[6-oxo-2-(2-propynyloxy)-4-trifluoromethyl-1(6H)-pyrimidinyl]-benzoate

HRID 1193871ノート

反応式

HRID 1193871 の反応式
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[N:17]=[C:16]2Cl)=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].[CH2:27]([OH:30])[C:28]#[CH:29]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[N:17]=[C:16]2[O:30][CH2:27][C:28]#[CH:29])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]

参加物

4

反応物 2

HCID 7859Propargyl alcoholHCID 19994245isopropyl 2-chloro-5-[2-chloro-6-oxo-4-trifluoromethyl-1(6H)-pyrimidinyl]-4-fluorobenzoate

生成物 1

HCID 21270783isopropyl 2-chloro-4-fluoro-5-[6-oxo-2-(2-propynyloxy)-4-trifluoromethyl-1(6H)-pyrimidinyl]-benzoate

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

using isopropyl 2-chloro-5-[2-chloro-6-oxo-4-trifluoromethyl-1(6H)-pyrimidinyl]-4-fluorobenzoate and propargyl alcohol with pyridine there is obtained isopropyl 2-chloro-4-fluoro-5-[6-oxo-2-(2-propynyloxy)-4-trifluoromethyl-1(6H)-pyrimidinyl]-benzoate, m.p. 117°-119° C.;

出典と根拠

ORDレコード
ord-dd9b995fa4384d65b8358da2cec3f944
出典データセット
uspto-grants-1989_03
特許番号
US04812164

反応ノート

読み込み中…