Thionyl Chloride → (S)-(-)-(3-Chloro-2-hydroxypropyl)trimethylammonium chloride

HRID 1194577ノート

反応式

HRID 1194577 の反応式
[Cl-:1].[OH:2][C@H:3]([CH2:9]O)[CH2:4][N+:5]([CH3:8])([CH3:7])[CH3:6].S(Cl)([Cl:13])=O>CN(C)C=O>[Cl-:13].[Cl:1][CH2:9][C@@H:3]([OH:2])[CH2:4][N+:5]([CH3:8])([CH3:7])[CH3:6]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 13668848(S)-2,3-Dihydroxy-N,N,N-trimethylpropan-1-aminium chloride

生成物 1

HCID 2793814(S)-(-)-(3-Chloro-2-hydroxypropyl)trimethylammonium chloride

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
100 °C

実験手順

Moreover, the obtained (S)-2,3-dihydroxypropyltrimethylammonium chloride was suspended in 100 ml of dimethylformamide and then 22.57 g of thionyl chloride was added thereto at a tempareture from 5° to 10° C. After stirring for 20 minutes, it was heated for 5 hours at 100° C. Finally, after the reaction was completed and the reaction mixture was cooled to room temperature, it was evaporated to dryness and then the residue was washed with methylene chloride to give 30.20 g of (S)-3-chloro-2-hydroxypropyltrimethylammonium chloride.

後処理

  1. customfrom 5° to 10° C
  2. temperaturethe reaction mixture was cooled to room temperature
  3. customit was evaporated to dryness
  4. washthe residue was washed with methylene chloride

出典と根拠

ORDレコード
ord-501095971757421a9354fc5a6bdb2e74
出典データセット
uspto-grants-1989_03
特許番号
US04814506

反応ノート

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