Hydrogen Bromide → HCID 135574541、化合物

HRID 1194609ノート

反応式

HRID 1194609 の反応式
C[O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13]C)[CH:9]=[N:8][CH:7]=[CH:6]2.[BrH:15]>C(O)(=O)C>[OH2:2].[BrH:15].[OH:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[OH:13])[CH:9]=[N:8][CH:7]=[CH:6]2

参加物

4

反応物 2

HCID 260Hydrogen BromideHCID 1775786,7-Dimethoxyisoquinoline

生成物 1

HCID 135574541HCID 135574541、化合物収率 88.4%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

1.9 g (10 mmol) of 6,7-dimethoxyisoquinoline was dissolved in a mixture of 15 ml of acetic acid and 15 ml of 40% hydrobromic acid, and the solution was stirred under reflux for 24 hours under a nitrogen atmosphere. The reaction solution was concentrated under reduced pressure. The residue was recrystallized from a 1N hydrobromic acid aqueous solution to obtain 2.3 g (yield: 88.4%) of the above identified compound. The melting point, infrared spectrum and NMR spectrum agreed to those of the compound of Reference Example 5.

後処理

  1. temperatureunder reflux for 24 hours under a nitrogen atmosphere
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. customThe residue was recrystallized from a 1N hydrobromic acid aqueous solution
  4. customto obtain 2.3 g (yield: 88.4%) of the

出典と根拠

ORDレコード
ord-dbb24cc3c9354b84aff558f6374d4d03
出典データセット
uspto-grants-1989_03
特許番号
US04814328

反応ノート

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