Hydrochloric Acid → HCID 11732720、化合物

HRID 1194892ノート

反応式

HRID 1194892 の反応式
Cl.[OH:2]/[N:3]=[C:4](/[C:10]1[N:11]=[C:12]([NH:15][C:16]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=2)[S:13][CH:14]=1)\[C:5]([O:7]CC)=[O:6].[OH-].[Na+].O.Cl>O1CCOCC1>[OH:2]/[N:3]=[C:4](/[C:10]1[N:11]=[C:12]([NH:15][C:16]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)([C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][CH:22]=2)[C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[S:13][CH:14]=1)\[C:5]([OH:7])=[O:6]

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 14798Sodium HydroxideHCID 9589415(Z)-Ethyl 2-(hydroxyimino)-2-(2-(tritylamino)thiazol-4-yl)acetate hydrochloride

生成物 1

HCID 11732720HCID 11732720、化合物収率 96.6%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

Ethyl (Z)-2-hydroxyimino-2-(2-tritylaminothiazol-4-yl)acetate hydrochloride (5 g) as a suspension in dioxane (50ml) was treated at room temperature with 1M aqueous sodium hydroxide (23 ml). After stirring for 12 h, water (50 ml) was added. The pH was adjusted to 1-2 with dilute hydrochloric acid. The resulting precipitate was filtered off, washed with water and dried over P2O5 to give the title compound (4.2 g) as a white solid; δH ((CD3)2SO) 6.73 (1H, s), 7.30 (15H, s).

後処理

  1. filtrationThe resulting precipitate was filtered off
  2. washwashed with water
  3. dry with materialdried over P2O5

出典と根拠

ORDレコード
ord-5f2ee8dcb68d4ee586eb30b4b0ac683e
出典データセット
uspto-grants-1989_03
特許番号
US04816452

反応ノート

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