Chlorotrimethylsilane → HCID 18608977、化合物

反応式

[OH:1][CH2:2][C@@H:3]1[CH:18]=[C:17]2[C@@H:7]([CH2:8][C:9]3[C:19]4[C:12](=[CH:13][CH:14]=[CH:15][C:16]2=4)[NH:11][CH:10]=3)[N:5]([CH3:6])[CH2:4]1.C[Si](C)(C)[Cl:22].C[Si](C)(C)Br>>[Cl:22][C:10]1[NH:11][C:12]2[C:19]3[C:9]=1[CH2:8][C@@H:7]1[C:17]([C:16]=3[CH:15]=[CH:14][CH:13]=2)=[CH:18][C@@H:3]([CH2:2][OH:1])[CH2:4][N:5]1[CH3:6]

参加物

反応物 3

HCID 6397Chlorotrimethylsilane

HCID 14987Lysergol

HCID 76113Bromotrimethylsilane

生成物 1

HCID 18608977HCID 18608977、化合物

実験手順

1 g of lysergol is halogenated according to the process of Example 1, except that 1.7 g of trimethylchlorosilane are used instead of trimethylbromosilane. The product is isolated as described in Example 1. The yield of the title compound is 0.73 g (0.0025347 mole, 64.4%), m.p.: 207° C.