3,3,3-Trifluoropropanal → (4R,9aR)-4-Methyl-6-((RS)-3,3,3-trifluoro-1-hydroxy-propyl)-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester

HRID 11951

反応式

HRID 11951 の反応式
[C:1]([O:5][C:6]([N:8]1[CH2:20][C@@H:19]([CH3:21])[N:18]2[C@H:10]([CH2:11][C:12]3[C:17]2=[N:16][C:15]([CH2:22][O:23]CCO)=[CH:14][CH:13]=3)[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].C([Li])(C)(C)C.[F:32][C:33]([F:38])([F:37])[CH2:34]C=O>>[C:1]([O:5][C:6]([N:8]1[CH2:20][C@@H:19]([CH3:21])[N:18]2[C@H:10]([CH2:11][C:12]3[C:17]2=[N:16][C:15]([CH:22]([OH:23])[CH2:34][C:33]([F:38])([F:37])[F:32])=[CH:14][CH:13]=3)[CH2:9]1)=[O:7])([CH3:3])([CH3:4])[CH3:2]

参加物

4

反応物 3

HCID 680283,3,3-TrifluoropropanalHCID 69557393(4R,9aR)-6-(2-hydroxy-ethoxymethyl)-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester2 回HCID 178418306HCID 178418306、化合物

生成物 1

HCID 69556370(4R,9aR)-4-Methyl-6-((RS)-3,3,3-trifluoro-1-hydroxy-propyl)-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester

実験手順

This compound was prepared in analogy to Example 38 intermediate, from (4R,9aR)-6-bromo-4-methyl-3,4,9,9a-tetrahydro-1H-2,4a,5-triaza-fluorene-2-carboxylic acid tert-butyl ester (Example 5, intermediate b), tert-butyllithium and 3,3,3-trifluoropropanal.

出典と根拠

ORDレコード
ord-e32ff7f058cb4325997af10b7ac9c6ab
出典データセット
uspto-grants-2006_08
特許番号
US07098337B2

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