Water → 5-Ethyl-5-(3-azidopropyl)barbituric acid
反応式
[CH2:1]([C:3]1([CH2:12][CH2:13][CH2:14]Br)[C:8](=[O:9])[NH:7][C:6](=[O:10])[NH:5][C:4]1=[O:11])[CH3:2].[N-:16]=[N+:17]=[N-:18].[Na+].O>CC(C)=O>[CH2:1]([C:3]1([CH2:12][CH2:13][CH2:14][N:16]=[N+:17]=[N-:18])[C:8](=[O:9])[NH:7][C:6](=[O:10])[NH:5][C:4]1=[O:11])[CH3:2]参加物
5
実験手順
A solution of 30 g of 5-ethyl-5-(3-bromopropyl) barbituric acid and 13 g of sodium azide in 350 ml of acetone was added to 240 ml of water and refluxed for approximately 18 hours. Thereafter, the solution was cooled on ice, filtered, air dried, and dissolved in a minimal amount of hot 95% ethanol. Crystals appeared after cooling and were filtered and air-dried. The melting point was 182°-184° C.
後処理
- temperaturerefluxed for approximately 18 hours
- temperatureThereafter, the solution was cooled on ice
- filtrationfiltered
- customair dried
- dissolutiondissolved in a minimal amount of hot 95% ethanol
- temperatureafter cooling
- filtrationwere filtered
- customair-dried
出典と根拠
- ORDレコード
- ord-1feefcd4bff247e08026f075ee81741d
- 出典データセット
- uspto-grants-1992_05
- 特許番号
- US05110914
反応ノート
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