ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

1-Chloro-4-nitrobenzene → 2-(4-Methylphenyl)-2-[4-(4-nitrophenoxy)phenyl]hexafluoropropane

HRID 1195446
ノート
印刷プレビュー

反応式

HRID 1195446 の反応式
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:17]2[CH:22]=[CH:21][C:20]([CH3:23])=[CH:19][CH:18]=2)([C:13]([F:16])([F:15])[F:14])[C:9]([F:12])([F:11])[F:10])=[CH:4][CH:3]=1.CC(N(C)C)=O.[OH-].[Na+].Cl[C:33]1[CH:38]=[CH:37][C:36]([N+:39]([O-:41])=[O:40])=[CH:35][CH:34]=1>C1(C)C=CC=CC=1.O>[CH3:23][C:20]1[CH:19]=[CH:18][C:17]([C:8]([C:5]2[CH:6]=[CH:7][C:2]([O:1][C:33]3[CH:38]=[CH:37][C:36]([N+:39]([O-:41])=[O:40])=[CH:35][CH:34]=3)=[CH:3][CH:4]=2)([C:9]([F:10])([F:11])[F:12])[C:13]([F:14])([F:15])[F:16])=[CH:22][CH:21]=1
参加物反応条件実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 74741-Chloro-4-nitrobenzeneHCID 14798Sodium HydroxideHCID 31374DimethylacetamideHCID 148323252-(4-Hydroxyphenyl)-2-(4-methylphenyl)hexafluoropropane

生成物 1

HCID 148323272-(4-Methylphenyl)-2-[4-(4-nitrophenoxy)phenyl]hexafluoropropane

試薬・触媒・溶媒 2

HCID 962
Water
溶媒
HCID 1140Toluene溶媒2 回

反応条件

温度
0 °C

実験手順

334 g (1 mol) of 2-(4-hydroxyphenyl)-2-(4-methylphenyl)hexafluoropropane, 1.2 dm3 of dimethylacetamide, 200 cm3 of toluene and 44 g of sodium hydroxide were refluxed until it was no longer possible to separate off any water of reaction using a water separator. The toluene was then removed by distillation, 164.4 g (1.1 mol) of 4-chloronitrobenzene were added, and the mixture was refluxed for 48 hours. After the mixture had been cooled to about 0° C., the solid was filtered off, washed with about 100 cm3 of dimethylacetamide and discarded. As much of the dimethylacetamide as possible was removed from the filtrate by vacuum distillation. The oily residue was taken up in 800 cm3 of methanol, a yellow solid precipitating out. The solid was separated off and dried. After the mother liquor had been worked up, a total of 325 g (71% of theory) of a yellow solid were obtained.

後処理

  1. customto separate off
  2. customany water of reaction
  3. additionwere added
  4. temperaturethe mixture was refluxed for 48 hours
  5. filtrationthe solid was filtered off
  6. washwashed with about 100 cm3 of dimethylacetamide
  7. customAs much of the dimethylacetamide as possible was removed from the filtrate by vacuum distillation
  8. customa yellow solid precipitating out
  9. customThe solid was separated off
  10. customdried
  11. customa total of 325 g (71% of theory) of a yellow solid were obtained

出典と根拠

ORDレコード
ord-4f902b2b5f8b4d4ba89397844ecb8bf2
出典データセット
uspto-grants-1992_05
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US05110983

反応ノート

読み込み中…

このページの内容参加物反応条件実験手順後処理出典と根拠反応ノート