Acetone → 3-Buten-2-one, 4-(2,3-dihydro-1H-inden-5-yl)-

HRID 1195455ノート

反応式

HRID 1195455 の反応式
[OH-].[Na+].[CH2:3]1[C:11]2[C:6](=[CH:7][C:8]([CH:12]=O)=[CH:9][CH:10]=2)[CH2:5][CH2:4]1.[CH3:14][C:15]([CH3:17])=[O:16]>O>[CH2:3]1[C:11]2[C:6](=[CH:7][C:8]([CH:12]=[CH:14][C:15](=[O:16])[CH3:17])=[CH:9][CH:10]=2)[CH2:5][CH2:4]1

参加物

5

反応物 3

HCID 180AcetoneHCID 14798Sodium HydroxideHCID 1216245-Indanecarboxaldehyde

生成物 1

HCID 40739273-Buten-2-one, 4-(2,3-dihydro-1H-inden-5-yl)-収率 81%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

An aqueous solution of 10% sodium hydroxide (50-70 ml) was added dropwise over a period of 5 minutes to a suspension of indane-5-carboxaldehyde (18.50 g; 127 mmole) in acetone (50 ml) and water (50 ml). The mixture was stirred at a temperature of 65° C. for a period of 11/2 hours and then extracted with dichloromethane (200 ml). The organic extract was washed several times with water, dried over anhydrous sodium sulphate, and the solvent was removed under reduced pressure using a rotary evaporator to give 1-(5-indanyl)but-1-en-3-one (19.25 g; 81%) as a viscous oil.

後処理

  1. extractionextracted with dichloromethane (200 ml)
  2. extractionThe organic extract
  3. washwas washed several times with water
  4. dry with materialdried over anhydrous sodium sulphate
  5. customthe solvent was removed under reduced pressure
  6. customa rotary evaporator

出典と根拠

ORDレコード
ord-bb8f46a3df0542a6981a9802cbb25294
出典データセット
uspto-grants-1992_05
特許番号
US05110989

反応ノート

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