Water → HCID 14010441、化合物

反応式

[Cl:1][C:2]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:3]=1[O:4][NH2:5].[CH3:11][O:12]CNC(Cl)=O.[OH2:18].[N:19]1[CH:24]=CC=C[CH:20]=1>>[Cl:1][C:2]1[CH:9]=[CH:8][C:7]([Cl:10])=[CH:6][C:3]=1[O:4][NH:5][C:20](=[O:18])[N:19]([O:12][CH3:11])[CH3:24]

参加物

反応物 4

HCID 962Water

HCID 1049Pyridine

HCID 135748982,5-Dichlorophenoxyamine

HCID 20240754Carbamic chloride, methoxymethyl-

生成物 1

HCID 14010441HCID 14010441、化合物収率 72%

実験手順

4.5 g (25 mmol) of 2,5-dichlorophenoxyamine was dissolved in 10 ml of pyridine, and then 5.6 g (38 mmol) of methoxymethylcarbamoyl chloride was added. The mixture was stirred at a temperature of from 25° to 30° C. for 12 hours. After an addition of 200 ml of water, the reaction mixture was extracted with ethyl acetate. The extract was washed with a saturated sodium chloride aqueous solution, and dried over anhydrous magnesium sulfate. Ethyl acetate was distilled off, and precipitated crystals were recrystallized from ethyl acetate-hexane, whereby 4.8 g of the desired product was obtained (yield: 72%).