Sodium borohydride → 3-Hydroxymethyl-8-(2-(trans)-hydroxy-2,3-dihydro-1-indenyloxy)-2-methyl-imidazo[1,2-a]pyridine

HRID 1195726ノート

反応式

HRID 1195726 の反応式
[CH:1]([C:3]1[N:7]2[CH:8]=[CH:9][CH:10]=[C:11]([O:12][C@@H:13]3[C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH2:15][C@H:14]3[OH:22])[C:6]2=[N:5][C:4]=1[CH3:23])=[O:2].[BH4-].[Na+]>CO>[OH:2][CH2:1][C:3]1[N:7]2[CH:8]=[CH:9][CH:10]=[C:11]([O:12][C@@H:13]3[C:21]4[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=4)[CH2:15][C@H:14]3[OH:22])[C:6]2=[N:5][C:4]=1[CH3:23]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 228438253-Formyl-8-(2-(trans)-hydroxy-2,3-dihydro-1-indenyloxy)-2-methyl-imidazo[1,2-a]pyridine

生成物 1

HCID 228438393-Hydroxymethyl-8-(2-(trans)-hydroxy-2,3-dihydro-1-indenyloxy)-2-methyl-imidazo[1,2-a]pyridine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

1 g of 3-formyl-8-(2-(trans)-hydroxy-2,3-dihydro-1-indenyloxy)-2-methyl-imidazo[1,2-a]pyridine is dissolved in 150 ml methanol, and excess sodium boro hydride is added in small portions at room temperature. After reduction has been completed, 150 ml icewater is added. The volatile components are evaporated in the rotary evaporator in vacuo. Subsequently extraction is carried out 3×with 40 ml ethyl acetate each time. The combined extracts are stripped off in vacuo of solvents, and the crystalline residue is recrystallized from methanol. The title compound of 192°-193° C. is obtained.

後処理

  1. addition150 ml icewater is added
  2. customThe volatile components are evaporated in the rotary evaporator in vacuo
  3. extractionSubsequently extraction
  4. customthe crystalline residue is recrystallized from methanol

出典と根拠

ORDレコード
ord-08b224fb8b06463da23e30973a23365f
出典データセット
uspto-grants-1992_05
特許番号
US05112834

反応ノート

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