Acetonitrile → HCID 14991366、化合物
反応式
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([CH3:12])[CH:10]=2)[N:5]=[C:4]([CH3:13])[CH:3]=1.[CH3:14][S-:15].[Na+].C(#N)C>O>[CH3:13][C:4]1[CH:3]=[C:2]([S:15][CH3:14])[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([CH3:12])[CH:10]=2)[N:5]=1参加物
5
実験手順
A mixture of 4-chloro-2,6-dimethylquinoline (0.5 g, prepared as described in Example 1), sodium thiomethoxide (0.55 g) and dry acetonitrile (20 ml) was heated to reflux under an atmosphere of argon for 15 hours. After cooling to laboratory temperature the mixture was poured into water (50 ml) and extracted with ethyl acetate (2×50 ml). The combined organic layers were dried over magnesium sulphate and evaporated to leave 2,6-dimethyl-4methylthioquinoline as a white solid (0.52 g) which was used without further purification.
後処理
- temperaturewas heated
- temperatureto reflux under an atmosphere of argon for 15 hours
- temperatureAfter cooling to laboratory temperature the mixture
- extractionextracted with ethyl acetate (2×50 ml)
- dry with materialThe combined organic layers were dried over magnesium sulphate
- customevaporated
出典と根拠
- ORDレコード
- ord-c296313bf6ac4033bb08018ebbb1a207
- 出典データセット
- uspto-grants-1992_05
- 特許番号
- US05112837
反応ノート
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