Trifluoroacetic acid → HCID 14368703、化合物

反応式

[C:1]1([C:7](C2C=CC=CC=2)(C2C=CC=CC=2)O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.FC(F)(F)C(O[C:26](=O)[C:27]([F:30])(F)F)=O.[F:34][C:35](F)(F)[C:36](O)=O>>[F:30][C:27]1[CH:26]=[C:35]([F:34])[CH:36]=[C:6]2[C:5]=1[CH:4]=[CH:3][CH:2]=[C:1]2[CH3:7]

参加物

反応物 3

HCID 6422Trifluoroacetic acid

HCID 6457Triphenylcarbinol

HCID 9845Trifluoroacetic anhydride

生成物 1

HCID 14368703HCID 14368703、化合物

実験手順

2.5 g of 5,7-Difluoro-1-methyl-tetralol, 3.6 g of triphenylmethanol and 2.6 g of trifluoroacetic acid anhydride are refluxed for 5 hours in 16 ml of trifluoroacetic acid. The mixture is poured onto ice-water and extracted with dichloromethane. The organic phase is washed neutral with sodium bicarbonate solution, dried and concentrated. The oily crude product can be purified by chromatography over silica gel (eluant:hexane).

後処理

additionThe mixture is poured onto ice-water
extractionextracted with dichloromethane
washThe organic phase is washed neutral with sodium bicarbonate solution
customdried
concentrationconcentrated
customThe oily crude product can be purified by chromatography over silica gel (eluant:hexane)

出典と根拠

ORDレコード: ord-ad67fd31fe2446d6979950a44886008f
出典データセット: uspto-grants-1992_05
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US05112851

反応ノート

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参加物