Water → 6,6-Dimethylpiperidine-2,4-dione
反応式
[CH3:1][C:2]1([CH3:14])[NH:7][C:6](=[O:8])[CH:5](C(OC)=O)[C:4](=[O:13])[CH2:3]1.O>Cl.C(#N)C>[CH3:1][C:2]1([CH3:14])[NH:7][C:6](=[O:8])[CH2:5][C:4](=[O:13])[CH2:3]1参加物
5
実験手順
A mixture of methyl 6,6-dimethylpiperidine-2,4-dione-3-carboxylate (26.3 g), water (30 ml) and concentrated hydrochloric acid (3 drops) in acetonitrile (300 ml) was heated at reflux for 4 hours. The cooled solution was evaporated under reduced pressure and the residue recrystallised from water (50 ml) to give 6,6-dimethylpiperidine-2,4-dione (7.3 g), mp 183°-184° C., as a cream crystalline solid.
後処理
- temperaturewas heated
- temperatureat reflux for 4 hours
- customThe cooled solution was evaporated under reduced pressure
- customthe residue recrystallised from water (50 ml)
出典と根拠
- ORDレコード
- ord-c5bf290599e847c09e4d88651cd7be55
- 出典データセット
- uspto-grants-1992_05
- 特許番号
- US05114461
反応ノート
読み込み中…