6-(Carbethoxymethyl)-3-phenyl-2-cyclohexen-1-one → 6-(Carbethoxymethyl)-3-phenylcyclohexanone

HRID 1196423ノート

反応式

HRID 1196423 の反応式
[C:1]([CH2:6][CH:7]1[C:12](=[O:13])[CH:11]=[C:10]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:9][CH2:8]1)([O:3][CH2:4][CH3:5])=[O:2]>[Pd].C(OCC)(=O)C>[C:1]([CH2:6][CH:7]1[C:12](=[O:13])[CH2:11][CH:10]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH2:9][CH2:8]1)([O:3][CH2:4][CH3:5])=[O:2]

参加物

4

反応物 1

HCID 216716106-(Carbethoxymethyl)-3-phenyl-2-cyclohexen-1-one

生成物 1

HCID 198983466-(Carbethoxymethyl)-3-phenylcyclohexanone収率 71%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

6-(Carbethoxymethyl)-3-phenyl-2-cyclohexen-1-one (2.11 g) was added to a mixture of 0.2 g of 10% palladium on carbon in 30 ml of ethyl acetate. The reaction mixture was hydrogenated under a hydrogen atmosphere (maximum pressure 45 psi) for 41 hours. The mixture was filtered through celite, and the solvent was removed under reduced pressure. The recovered crude oil product was purified by chromatography on silica gel eluted with 5% ethyl acetate in hexane to provide 1.5 g (71%) of 6-(carbethoxymethyl)-3-phenylcyclohexanone.

後処理

  1. customfor 41 hours
  2. filtrationThe mixture was filtered through celite
  3. customthe solvent was removed under reduced pressure
  4. customThe recovered crude oil product
  5. customwas purified by chromatography on silica gel
  6. washeluted with 5% ethyl acetate in hexane

出典と根拠

ORDレコード
ord-7c46a809bee84b7e9caf67792ad49c77
出典データセット
uspto-grants-1992_05
特許番号
US05114493

反応ノート

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