Thionyl Chloride → 4-(4-Trifluoromethylbenzyloxy)-2-chloromethylpyridine

HRID 1196623ノート

反応式

HRID 1196623 の反応式
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:18]=[CH:17][C:6]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([CH2:15]O)[CH:10]=2)=[CH:5][CH:4]=1.S(Cl)([Cl:23])=O>ClCCl>[F:1][C:2]([F:20])([F:19])[C:3]1[CH:18]=[CH:17][C:6]([CH2:7][O:8][C:9]2[CH:14]=[CH:13][N:12]=[C:11]([CH2:15][Cl:23])[CH:10]=2)=[CH:5][CH:4]=1

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 144259724-(4-Trifluoromethylbenzyloxy)-2-hydroxymethylpyridine

生成物 1

HCID 144259864-(4-Trifluoromethylbenzyloxy)-2-chloromethylpyridine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

2.2 g (7.8 mmol) of the title compound from Example 3 are dissolved in 50 ml of anhydrous dichloromethane and a solution of 2 ml of thionyl chloride in 6 ml of dichloromethane is added dropwise at -10° C. The mixture is warmed to room temperature, stirred for 30 minutes more, and concentrated. The crystalline residue is brought to crystallization using diisopropyl ether and dried using an oilpump, m.p. 133°-135° C.

後処理

  1. concentrationconcentrated
  2. customThe crystalline residue is brought to crystallization
  3. customdried

出典と根拠

ORDレコード
ord-a9a3fc14b80044d4ada986a19f0862a4
出典データセット
uspto-grants-1992_05
特許番号
US05114955

反応ノート

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