L-Cysteine, N-acetyl-S-ethyl- → 21-[2-(Acetylamino)-3-etylthio-1-oxopropylthio]-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione

HRID 1196832

反応式

HRID 1196832 の反応式
[F:1][C@:2]12[CH:22]([OH:23])[CH2:21][C@@:20]3([CH3:24])[C@@H:12]([CH2:13][C@H:14]([CH3:26])[C@:15]3([OH:25])[C:16](=[O:19])[CH2:17][SH:18])[C@@H:11]1[CH2:10][CH2:9][C:8]1[C@:3]2([CH3:28])[CH:4]=[CH:5][C:6](=[O:27])[CH:7]=1.[C:29]([NH:32][C@H:33]([C:38](O)=[O:39])[CH2:34][S:35][CH2:36][CH3:37])(=[O:31])[CH3:30]>>[C:29]([NH:32][CH:33]([CH2:34][S:35][CH2:36][CH3:37])[C:38](=[O:39])[S:18][CH2:17][C:16](=[O:19])[C@:15]1([OH:25])[C@:20]2([CH3:24])[C@H:12]([C@H:11]3[C@:2]([F:1])([C@@H:22]([OH:23])[CH2:21]2)[C@:3]2([CH3:28])[C:8](=[CH:7][C:6](=[O:27])[CH:5]=[CH:4]2)[CH2:9][CH2:10]3)[CH2:13][C@@H:14]1[CH3:26])(=[O:31])[CH3:30]

参加物

3

反応物 2

HCID 147382L-Cysteine, N-acetyl-S-ethyl-HCID 1317174029-Fluoro-11,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione-21-thiol

生成物 1

HCID 8839537421-[2-(Acetylamino)-3-etylthio-1-oxopropylthio]-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione収率 29.5%

実験手順

The title compound (0.21 gm) was prepared from 9-fluoro-11 ,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione-21-thiol (0.5 gm) and N-acetyl-S-ethylcysteine (0.70 gm) in the same manner as in Synthetic Example 1.

出典と根拠

ORDレコード
ord-8cb11f885d7e46b78341dadba13e2a42
出典データセット
uspto-grants-1992_05
特許番号
US05116829

関連ノート

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