Methyl iodide → 1-(2,4-Difluorophenyl)-2-(pyridin-3-yl)propan-1-one

HRID 1196939ノート

反応式

HRID 1196939 の反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:17])[CH2:10][C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1.I[CH3:19]>>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:17])[CH:10]([C:11]1[CH:12]=[N:13][CH:14]=[CH:15][CH:16]=1)[CH3:19]

参加物

3

反応物 2

HCID 6328Methyl iodideHCID 189565241-(2,4-Difluorophenyl)-2-(3-pyridinyl)-ethanone

生成物 1

HCID 189565411-(2,4-Difluorophenyl)-2-(pyridin-3-yl)propan-1-one収率 73.6%

実験手順

Methylation of the product of part (i) (5.0 g) with iodomethane (7.60 g) according to the method of Example 11(ii) gave the title compound as an oil (3.90 g) which was used directly in the next stage.

出典と根拠

ORDレコード
ord-e3fe0713b35d4230a8b3914976606637
出典データセット
uspto-grants-1992_05
特許番号
US05116844

反応ノート

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