Tetrahydrofuran → 2-(2,4-Difluorophenyl)-2-[1-(pyridin-3-yl)ethyl]oxirane

HRID 1196940ノート

反応式

HRID 1196940 の反応式
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9](=[O:18])[CH:10]([C:12]1[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=1)[CH3:11].O1CCC[CH2:20]1>O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1([CH:10]([C:12]2[CH:13]=[N:14][CH:15]=[CH:16][CH:17]=2)[CH3:11])[CH2:20][O:18]1

参加物

4

反応物 2

HCID 8028Tetrahydrofuran2 回HCID 189565411-(2,4-Difluorophenyl)-2-(pyridin-3-yl)propan-1-one

生成物 1

HCID 189565362-(2,4-Difluorophenyl)-2-[1-(pyridin-3-yl)ethyl]oxirane

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A solution of dimethylsulphoxonium methylide (36.5 ml of a 0.6M solution in tetrahydrofuran) was added dropwise to a stirred solution of the product of part (ii) (4.36 g) in tetrahydrofuran (35 ml) at -20°. The solution was allowed to warm to room temperature and stirring was continued for 18 hours and then diluted with water. The mixture was extracted with ethyl acetate and the combined extracts were dried (Na2SO4). Evaporation of the solvent gave the title compound as an oil (4.50 g) which was used directly in the next stage.

後処理

  1. extractionThe mixture was extracted with ethyl acetate
  2. dry with materialthe combined extracts were dried (Na2SO4)
  3. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-d9b0338e36fb46c6a526f8607780570b
出典データセット
uspto-grants-1992_05
特許番号
US05116844

反応ノート

読み込み中…