Hydrochloric Acid → HCID 178462135、化合物

HRID 1197072ノート

反応式

HRID 1197072 の反応式
[N:1]1(C(OCC2C=CC=CC=2)=O)[C:5](=[O:6])[CH2:4][CH2:3][C@H:2]1[C:7]([NH:9][C@H:10]([C:12]([NH:14][C@H:15]([C:26]([OH:28])=[O:27])[CH2:16][CH2:17][CH2:18][NH:19][C:20](=[NH:25])[NH:21][N+]([O-])=O)=[O:13])[CH3:11])=[O:8].CO.Cl>[Pd].O>[NH:1]1[C:5](=[O:6])[CH2:4][CH2:3][C@H:2]1[C:7]([NH:9][C@H:10]([C:12]([NH:14][C@H:15]([C:26]([OH:28])=[O:27])[CH2:16][CH2:17][CH2:18][NH:19][C:20](=[NH:21])[NH2:25])=[O:13])[CH3:11])=[O:8]

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 178462136HCID 178462136、化合物

生成物 1

HCID 178462135HCID 178462135、化合物収率 50.8%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 962Water溶媒

実験手順

After 1.75 g (2.6 mmols) of Z-PyroGlu-Ala-Arg(NO2)-CHA was suspended in a solvent mixture of 112.5 ml of MeOH, 27.7 ml of H2O and 9.8 ml of 1N-HCl, 1 g of palladium black was added to the suspension followed by catalytic reduction at 30° C. for 6 hours. After the reaction, the catalyst was filtered off and the solvent was removed by distillation under reduced pressure. The residue was purified through TOYOPEARL HW40F column using MeOH as a developing solvent to give 0.471 g (34.4%) of H-PyroGlu-Ala-Arg-CHA.HCl.

後処理

  1. additionwas added to the suspension
  2. customAfter the reaction
  3. filtrationthe catalyst was filtered off
  4. customthe solvent was removed by distillation under reduced pressure
  5. customThe residue was purified through TOYOPEARL HW40F column

出典と根拠

ORDレコード
ord-aeaa3c673fd643ca9ee65199d01496ef
出典データセット
uspto-grants-1992_05
特許番号
US05116941

反応ノート

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