Formaldehyde → 4-(1-Methylethyl)-N-(2-thienylmethyl)benzamide

HRID 1197146ノート

反応式

HRID 1197146 の反応式
[S:1]1[CH:5]=[CH:4][CH:3]=[CH:2]1.[CH2:6]=O.[CH:8]([C:11]1[CH:19]=[CH:18][C:14]([C:15]([NH2:17])=[O:16])=[CH:13][CH:12]=1)([CH3:10])[CH3:9]>C(O)=O>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][NH:17][C:15](=[O:16])[C:14]1[CH:18]=[CH:19][C:11]([CH:8]([CH3:10])[CH3:9])=[CH:12][CH:13]=1

参加物

5

反応物 3

HCID 712FormaldehydeHCID 8030ThiopheneHCID 69277Benzamide, 4-(1-methylethyl)-

生成物 1

HCID 45979094-(1-Methylethyl)-N-(2-thienylmethyl)benzamide収率 80%

試薬・触媒・溶媒 1

HCID 284Formic Acid溶媒

実験手順

Thiophene (50 mmol), formaldehyde (10 mmol) and 4-isopropylbenzamide (10 mmol}were stirred in formic acid (10 ml) at 20° C. for four hours and treated in the same manner as in Example 2 to obtain N-(2-thienylmethyl)-4-isopropylbenzamide. Yield: 80%.

後処理

  1. additiontreated in the same manner as in Example 2

出典と根拠

ORDレコード
ord-81266c2dd6f944b9b8197a1d93de06ed
出典データセット
uspto-grants-1992_05
特許番号
US05117000

反応ノート

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