2-O-Methyl-1,3-O,O-benzylideneglycerol → 1-O-benzyl-2-O-methylglycerol

HRID 1197158ノート

反応式

HRID 1197158 の反応式
[C:1]1([CH:7]2[O:12][CH2:11][CH:10]([O:13][CH3:14])[CH2:9][O:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>O1CCCC1>[CH2:7]([O:8][CH2:9][CH:10]([O:13][CH3:14])[CH2:11][OH:12])[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

3

反応物 1

HCID 1285142-O-Methyl-1,3-O,O-benzylideneglycerol

生成物 1

HCID 1294271-O-benzyl-2-O-methylglycerol収率 62%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

反応条件

温度
0 °C

実験手順

4.2 g of 2b was dissolved in 10 ml of tetrahydrofuran at 0° C. A solution of BH3 in tetrahydrofuran (1M, 30 ml) was added slowly, under stirring. Stirring was continued for 48 hours at room temperature. The mixture was then cooled to 0° C., quenched with cold water and extracted with diethyl ether. The solvent was eliminated and the crude product was chromatographed (eluent petroleum ether/diethyl ether, successively 80:20 and 70:30 by volume), yielding 2.6 g of 3b (62%).

後処理

  1. stirringStirring
  2. customquenched with cold water
  3. extractionextracted with diethyl ether
  4. customthe crude product was chromatographed (eluent petroleum ether/diethyl ether, successively 80:20 and 70:30 by volume),

出典と根拠

ORDレコード
ord-93c70e656f0a483f9e464bdad4b45d31
出典データセット
uspto-grants-1992_05
特許番号
US05116992

反応ノート

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