2-(Hex-5-ynyl)malonic acid → 7-Octynoic acid
反応式
[CH2:1]([CH:7](C(O)=O)[C:8]([OH:10])=[O:9])[CH2:2][CH2:3][CH2:4][C:5]#[CH:6]>C(#N)C>[C:8]([OH:10])(=[O:9])[CH2:7][CH2:1][CH2:2][CH2:3][CH2:4][C:5]#[CH:6]参加物
3
実験手順
A mixture of 2-(hex-5-ynyl)malonic acid (2.2 g) and cuprous oxide (60 mg) in dry acetonitrile (40 ml) was stirred and refluxed, under nitrogen, for 6 hours. The solvent was removed in vacuo. 5% Aqueous hydrochloric acid was added and the aqueous mixture was extracted with diethyl ether. The ethereal extracts were dried over anhydrous magnesium sulphate and the solvent was removed in vacuo. Oct-7-ynoic acid was obtained as an oil (1.5 g) and was used without further purification.
後処理
- temperaturerefluxed, under nitrogen, for 6 hours
- customThe solvent was removed in vacuo
- addition5% Aqueous hydrochloric acid was added
- extractionthe aqueous mixture was extracted with diethyl ether
- dry with materialThe ethereal extracts were dried over anhydrous magnesium sulphate
- customthe solvent was removed in vacuo
出典と根拠
- ORDレコード
- ord-be8fb9c6dfd74b03bf3a33971a125ced
- 出典データセット
- uspto-grants-1992_05
- 特許番号
- US05116862
反応ノート
読み込み中…