Acetic Anhydride → Ethyl 1-acetyl-4-oxo-3-piperidinecarboxylate

HRID 1198462

反応式

HRID 1198462 の反応式
[C:1]([CH:6]1[C:11](=[O:12])[CH2:10][CH2:9][NH:8][CH2:7]1)([O:3][CH2:4][CH3:5])=[O:2].[C:13](OC(=O)C)(=[O:15])[CH3:14]>C(=O)([O-])[O-].[Na+].[Na+]>[C:13]([N:8]1[CH2:9][CH2:10][C:11](=[O:12])[CH:6]([C:1]([O:3][CH2:4][CH3:5])=[O:2])[CH2:7]1)(=[O:15])[CH3:14]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 1073164-Oxo-piperidine-3-carboxylic acid ethyl ester

生成物 1

HCID 12445847Ethyl 1-acetyl-4-oxo-3-piperidinecarboxylate

試薬・触媒・溶媒 1

HCID 10340Sodium Carbonate溶媒

実験手順

To a vigorously stirred, ice-water cooled suspension of 2.0 g of 3-carbethoxy-4-piperidone in 20 ml of aqueous sodium carbonate is added 1 ml of acetic anhydride. The mixture is stirred in the cold for 30 minutes then extracted with ether. The organic layer is dried and evaporated to afford 1.5 g of colorless solid, m.p. 53°-55° C.

後処理

  1. stirringThe mixture is stirred in the cold for 30 minutes
  2. extractionthen extracted with ether
  3. customThe organic layer is dried
  4. customevaporated

出典と根拠

ORDレコード
ord-a5433ca7aab142e2b391e1c03e0af46d
出典データセット
uspto-grants-1994_01
特許番号
US05281602

関連ノート

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