Ethyl Acetate → HCID 14988431、化合物
反応式
[C:1]1(=[O:14])[C:11]2=[C:12]3[C:7](=[CH:8][CH:9]=[CH:10]2)[CH2:6][CH2:5][CH2:4][N:3]3[C:2]1=[O:13].[Br:15]N1C(=O)CCC1=O.C(OCC)(=O)C>CN(C=O)C>[Br:15][C:9]1[CH:8]=[C:7]2[C:12]3=[C:11]([C:1](=[O:14])[C:2](=[O:13])[N:3]3[CH2:4][CH2:5][CH2:6]2)[CH:10]=1参加物
5
実験手順
A mixture of 5,6-dihydro-4H-pyrrolo[3,2,1-ij]quinoline-1,2-dione (10 g) and N-bromosuccinimide (10 g) in DMF (60 ml) was stirred at 7020 C. for 5 hours. After cooling, to the mixture was added ethyl acetate (500 ml) and washed with water and saturated aqueous sodium chloride solution successively, and then dried over anhydrous sodium sulfate. Evaporation of ethyl acetate afforded the title compound. The compound was recrystallized from ethanol to give 14 g (98.4%) as dark red needles.
後処理
- temperatureAfter cooling, to the mixture
- washwashed with water and saturated aqueous sodium chloride solution successively
- dry with materialdried over anhydrous sodium sulfate
- customEvaporation of ethyl acetate
出典と根拠
- ORDレコード
- ord-6d3b7d39f6ed4ef99500f80b90776203
- 出典データセット
- uspto-grants-1994_01
- 特許番号
- US05281600
反応ノート
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