Water → HCID 178441853、化合物

HRID 1198482ノート

反応式

HRID 1198482 の反応式
[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10](I)=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4].[Cu][C:18]#[N:19].O>N1C=CC=CC=1>[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10]([C:18]#[N:19])=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4]

参加物

5

反応物 3

HCID 962WaterHCID 178418546HCID 178418546、化合物HCID 178441862HCID 178441862、化合物

生成物 1

HCID 178441853HCID 178441853、化合物収率 72.2%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

A mixture of 6.4 g of 2-butyl-6-iodo-4(1H)-quinazolinone in 25 ml of pyridine is added 3.6 g of copper(I) cyanide followed by heating at reflux for 16 hours. The reaction mixture is poured into water and stirred at room temperature for 8 hours. The suspension is filtered and the cake washed well with water and air dried. The solid is dissolved in 3:1 chloroform-methanol and dried with MgSO4. The volatiles are evaporated in vacuo to give 3.2 g of the desired product as a solid. m.p. 243°-45° C.

後処理

  1. temperatureby heating
  2. temperatureat reflux for 16 hours
  3. filtrationThe suspension is filtered
  4. washthe cake washed well with water and air
  5. customdried
  6. dissolutionThe solid is dissolved in 3:1 chloroform-methanol
  7. dry with materialdried with MgSO4
  8. customThe volatiles are evaporated in vacuo

出典と根拠

ORDレコード
ord-66ca6f44ce0b4c5a8dbd1084a5d79e51
出典データセット
uspto-grants-1994_01
特許番号
US05281603

反応ノート

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