Hydrochloric Acid → HCID 178441834、化合物

HRID 1198483ノート

反応式

HRID 1198483 の反応式
[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10]([C:16]#[N:17])=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4].C([Sn](Cl)(CCCC)CCCC)CCC.[N-:32]=[N+:33]=[N-:34].[Na+].Cl>C1(C)C=CC=CC=1.CCCCCC>[CH2:1]([C:5]1[NH:6][C:7]2[C:12]([C:13](=[O:15])[N:14]=1)=[CH:11][C:10]([C:16]1[NH:34][N:33]=[N:32][N:17]=1)=[CH:9][CH:8]=2)[CH2:2][CH2:3][CH3:4]

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 15096Tributyltin ChlorideHCID 33557Sodium AzideHCID 178441853HCID 178441853、化合物

生成物 1

HCID 178441834HCID 178441834、化合物収率 114.7%

試薬・触媒・溶媒 2

HCID 1140Toluene溶媒HCID 8058Hexane溶媒

実験手順

A mixture of 1.1 g of 2-Butyl-6-cyano-4(1H)-quinazolinone 3.2 g of tri-n-butyltin chloride and 640 mg of sodium azide in 30 ml of toluene is heated at reflux for 48 hours. The reaction mixture is cooled to room temperature and dry HCl gas passed through the reaction mixture for 10 minutes. The reaction mixture is diluted with hexane and filtered. The residue is dried, washed with water and dried to give 1.5 g of the desired product as a solid, m.p. 225° C.

後処理

  1. temperatureis heated
  2. temperatureat reflux for 48 hours
  3. filtrationfiltered
  4. customThe residue is dried
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-d82ea002fedf428bb9aef779f175b0f7
出典データセット
uspto-grants-1994_01
特許番号
US05281603

反応ノート

読み込み中…