Hydrazine hydrate (1:1) → KF-19418
反応式
[C:1]([C:9]1[C:10](=[O:26])[N:11]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[C:12]2[C:17]([C:18]=1O)=[CH:16][CH:15]=[CH:14][N:13]=2)(=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[NH2:28][NH2:29]>C(O)(=O)C>[C:2]1([C:1]2[C:9]3[C:10](=[O:26])[N:11]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[C:12]4[N:13]=[CH:14][CH:15]=[CH:16][C:17]=4[C:18]=3[NH:29][N:28]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1参加物
4
実験手順
850 mg (2.5 millimoles) of Compound 101 was suspended in 5 ml of glacial acetic acid, and 0.26 ml (5.5 millimoles) of hydrazine monohydrate was added to the suspension. The mixture was heated under reflux for 5 hours and the reaction mixture was cooled to room temperature. The precipitate was collected by filtration, and recrystallized from DMF-water to obtain 440 mg (yield 52.4%) of Compound 1.