関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Dichloromethane | HCID 6344 | — |
| 反応物 | Diisobutylaluminum hydride | HCID 14487 | — |
| 反応物 | trans-3-[2-(7-Chloroquinolin-2-yl)ethenyl]benzyl alcohol | HCID 10827738 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 3-[2(E)-(2-Pyridyl)ethenyl]benzyl alcohol | HCID 70341855 | — |
反応手順
The methyl benzoate (Example 37b part ii) (2.25 g, 9.4 mmol) was dissolved in dry toluene (60 ml) and cooled to -70° C. under nitrogen. 1M DIBAL in dichloromethane (18.8 ml, 18.8 mmol) was added over 15 minutes and the reaction mixture allowed to warm up to -30° C. for 30 minutes. The reaction was quenched by careful addition of methanol (8 ml), then water, and after filtration through Celite the organic phase was evaporated in vacuo.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05281593 |
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| 出典データセット | uspto-grants-1994_01 |
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| ORD ID | ord-f12ccb71f6ac4577a2b2f68c674ebacb |
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| 出典メモ | uspto-grants-1994_01 |
|---|
