反应详情

温度

-70 °C

The methyl benzoate (Example 37b part ii) (2.25 g, 9.4 mmol) was dissolved in dry toluene (60 ml) and cooled to -70° C. under nitrogen. 1M DIBAL in dichloromethane (18.8 ml, 18.8 mmol) was added over 15 minutes and the reaction mixture allowed to warm up to -30° C. for 30 minutes. The reaction was quenched by careful addition of methanol (8 ml), then water, and after filtration through Celite the organic phase was evaporated in vacuo.

1. temperatureto warm up to -30° C. for 30 minutes
2. customThe reaction was quenched by careful addition of methanol (8 ml)
3. filtrationwater, and after filtration through Celite the organic phase
4. customwas evaporated in vacuo