4-Pyridineethanol → 4-(2-Hydroxyethyl)pyridine-2-carbonitrile
反応式
[OH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][N:7]=[CH:6][CH:5]=1.OCCC1C=C[N+:16]([O-])=[CH:15]C=1.C[Si](C#N)(C)C>>[OH:1][CH2:2][CH2:3][C:4]1[CH:9]=[CH:8][N:7]=[C:6]([C:15]#[N:16])[CH:5]=1参加物
4
実験手順
4-(2-hydroxyethyl)-pyridine is oxidized to 4-(2-hydroxyethyl)-pyridine-N-oxide which is in turn treated with trimethylsilyl cyanide to yield 4-(2-hydroxyethyl)-2-cyanopyridine which is converted to ethyl 4-(2-hydroxyethyl)-2-pyridine carboxylate and then hydrogenated to yield ethyl 4-(2-hydroxyethyl)-piperidine-2-carboxylate.
出典と根拠
- ORDレコード
- ord-dc6b41ac6b624a5cad57450055d167b0
- 出典データセット
- uspto-grants-1990_02
- 特許番号
- US04898854
反応ノート
読み込み中…