Water → 2-(2-Iodo-5-methoxyphenyl)acetic acid
反応式
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH2:9][C:10]([OH:12])=[O:11])[CH:6]=[CH:7][CH:8]=1.[I:13]Cl.O>C(O)(=O)C.II>[I:13][C:6]1[CH:7]=[CH:8][C:3]([O:2][CH3:1])=[CH:4][C:5]=1[CH2:9][C:10]([OH:12])=[O:11]参加物
6
実験手順
A solution of 45 g (0.27 mole) of 3-methoxybenzeneacetic acid, 52.6 g (0.32 mole) of iodine monochloride and 1 g of iodine was allowed to stand in 500 ml of glacial acetic acid for six days at room temperature. The reaction was poured into water and the solid collected. It was recrystallized from toluene to give 51 g of crystalline 2-iodo-5-methoxybenzeneacetic acid, mp 133.5°-134.5° C. (65% yield).
後処理
- customthe solid collected
- customIt was recrystallized from toluene
出典と根拠
- ORDレコード
- ord-577c39de1e3b494d871a067200fb5e1c
- 出典データセット
- uspto-grants-1990_02
- 特許番号
- US04898889
反応ノート
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