反応式
[CH3:1][C:2]1[C:3]([S:8]([NH2:11])(=[O:10])=[O:9])=[N:4][CH:5]=[CH:6][CH:7]=1.C1(N[C:19](=O)[O-:20])C=CC=CC=1.[CH3:22][C:23]1[CH:28]=[C:27]([CH3:29])[N:26]=[C:25]([NH2:30])[N:24]=1.C1CCN2C(=NCCC2)CC1.Cl.[OH2:43]>CC#N>[CH3:22][C:23]1[CH:28]=[C:27]([CH3:29])[N:26]=[C:25]([NH:30][C:19]([NH:11][S:8]([C:3]2[N+:4]([O-:43])=[CH:5][CH:6]=[CH:7][C:2]=2[CH3:1])(=[O:10])=[O:9])=[O:20])[N:24]=1参加物
8
反応物 6
生成物 1
試薬・触媒・溶媒 1
実験手順
To a stirring solution of the N-oxide of 3-methyl-2-pyridinesulfonamide (150 mg, 0.79 mmol) and the phenylcarbamate of 4,6-dimethyl-2-aminopyrimidine (194 mg, 0.79 mmol) in 3 mL of CH3CN was added DBU (121 mg, 0.79 mmol). The solution was stirred for 15 minutes. Three mL of H2O, then 3 mL of 5% HCl was added to the reaction and the resulting solid was collected,d m.p. 161°-163° C. NMR (200 MHz, d6 -DMS0) δ 2,36 (s, 6H), 2.59 (s, 3H), 6.97 (s, 1H), 7.4 (d, 1H), 7.5 (d, 1H), 8.3 (d, 1H), 10.6 (br s, 1H) and 13.3 (br s, 1H).
出典と根拠
- ORDレコード
- ord-f5f749710f3f412ab04d2b7bc074b7aa
- 出典データセット
- uspto-grants-1990_02
- 特許番号
- US04900353
関連ノート
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