Anisole → HCID 178503585、化合物

HRID 1199348ノート

反応式

HRID 1199348 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6](=[CH:12][CH:13]=1)[N:7]=[C:8]([S:10][CH3:11])[N:9]=2.[C:14]1(OC)C=CC=CC=1.[F:22][C:23]([F:30])([F:29])[S:24]([O:27]C)(=[O:26])=[O:25]>C(OCC)(=O)C>[F:22][C:23]([F:30])([F:29])[S:24]([O-:27])(=[O:26])=[O:25].[CH3:14][N:9]1[C:5]2=[CH:4][CH:3]=[C:2]([CH3:1])[CH:13]=[CH:12][C:6]2=[NH+:7][CH:8]1[S:10][CH3:11]

参加物

5

反応物 3

HCID 7519AnisoleHCID 9526Methyl triflateHCID 200643756-Methyl-2-(methylsulfanyl)cyclohepta[d]imidazole

生成物 1

HCID 178503585HCID 178503585、化合物

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

6-Methyl-2-methylthiocycloheptimidazole (27 g) was added to 100 ml of anisole and stirred under ice cooling. Then, 28 g of methyl trifluoromethanesulfonate was added dropwise thereto, and stirred under ice cooling. The mixture was further stirred at room temperature for one hour, 200 ml of ethyl acetate was added, and deposited crystals were collected by filtration and dried.

後処理

  1. stirringstirred under ice cooling
  2. stirringThe mixture was further stirred at room temperature for one hour
  3. filtrationwere collected by filtration
  4. customdried

出典と根拠

ORDレコード
ord-a7d3fe9e3ec64f6fab616d0207dc7023
出典データセット
uspto-grants-1990_02
特許番号
US04900648

反応ノート

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