Sodium Hydroxide → S-Nitrosocaptopril
反応式
[CH3:1][C@@H:2]([C:5]([N:7]1[C@H:11]([C:12]([OH:14])=[O:13])[CH2:10][CH2:9][CH2:8]1)=[O:6])[CH2:3][SH:4].[N:15]([O-])=[O:16].[Na+].[OH-].[Na+]>Cl>[CH3:1][C@@H:2]([C:5]([N:7]1[C@H:11]([C:12]([OH:14])=[O:13])[CH2:10][CH2:9][CH2:8]1)=[O:6])[CH2:3][S:4][N:15]=[O:16]参加物
5
実験手順
50 mg of Captopril (0.236 mMoles) was dissolved in 10 ml of 0.1 M HCl at room temperature and cooled briefly in an ice bath. A total of 0.25 ml of 1 M NaNO2 was then added in several small portions with rapid swirling. After 2 min on ice, 1.0 ml of 0.5 M Na2HPO4 was added and the solution was adjusted to pH 7.3 with 0.1 M NaOH. The solution displayed absorption maxima at 542 nm (E=19.8 M-1 cm-1) and 330 nm (E=995 M-1 cm-1).
後処理
- temperaturecooled briefly in an ice bath
- customabsorption maxima at 542 nm (E=19.8 M-1 cm-1) and 330 nm (E=995 M-1 cm-1)
出典と根拠
- ORDレコード
- ord-13d06335fb874e1e83d7f5a74d0a5141
- 出典データセット
- uspto-grants-1990_02
- 特許番号
- US04900719
反応ノート
読み込み中…