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2-Aminopyridine → 2-(2-Bromophenyl)imidazo[1,2-a]pyridine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminopyridine | HCID 10439 | — |
| 反応物 | 2-Bromophenacyl Bromide | HCID 2737522 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-(2-Bromophenyl)imidazo[1,2-a]pyridine | HCID 2862388 | — |
反応手順
A solution of 2-aminopyridine (1.63 g) and 2-bromo-1-(2-bromophenyl)-ethanone (4.8 g) in dry ethanol (40 mls) was heated under reflux for 1 hour. The mixture was concentrated in vacuo. The residue was treated with dilute sodium bicarbonate solution and extracted with ethyl acetate. The ethyl acetate was washed with water and brine then dried and evaporated. Flash chromatography produced the sub-title compound as a light grey oil. MS MW 272/274 bp 272.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04900751 |
| 出典データセット | uspto-grants-1990_02 |
| ORD ID | ord-5dac21755698435cbc12774be3fba360 |
| 出典メモ | uspto-grants-1990_02 |