Hydrochloric Acid → cis 4-Thiocyanatomethyl-3-amino-2-oxo-azetidine hydrochloride
反応式
[S:1]([CH2:4][C@H:5]1[NH:8][C:7](=[O:9])[C@H:6]1[N:10]1C(=O)C2=CC=CC=C2C1=O)[C:2]#[N:3].O.NN.[ClH:24]>O1CCOCC1>[ClH:24].[S:1]([CH2:4][C@H:5]1[NH:8][C:7](=[O:9])[C@H:6]1[NH2:10])[C:2]#[N:3]参加物
5
反応条件
- 温度
- 20 °C
実験手順
A hot mixture of 1.45 g of the product of Step B in 15 ml of hot dioxane was cooled and 0.3 ml of hydrazine hydrate was added thereto. The mixture was stirred for 50 minutes at 20° C. and 7.5 ml of N hydrochloric acid were added thereto. The mixture was stirred for 15 hours and vacuum filtered. The filtrate was rinsed with water and the filtrate was evaporated to dryness to obtain 0.914 g of cis 4-thiocyanatomethyl-3-amino-2-oxo-azetidine hydrochloride.
後処理
- temperaturewas cooled
- stirringThe mixture was stirred for 15 hours
- filtrationvacuum filtered
- washThe filtrate was rinsed with water
- customthe filtrate was evaporated to dryness
出典と根拠
- ORDレコード
- ord-6af5fcba448a4060a8af398bef1a3685
- 出典データセット
- uspto-grants-1990_02
- 特許番号
- US04900728
反応ノート
読み込み中…