HCID 14989639、化合物 → 5-amino-2-Pyridinepropanoic acid

HRID 1199684ノート

反応式

HRID 1199684 の反応式
[N+:1]([C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[N:8][CH:9]=1)([O-])=O>C(O)C.[Pd]>[NH2:1][C:4]1[CH:5]=[CH:6][C:7]([CH2:10][CH2:11][C:12]([OH:14])=[O:13])=[N:8][CH:9]=1

参加物

4

反応物 1

HCID 14989639HCID 14989639、化合物

生成物 1

HCID 149896425-amino-2-Pyridinepropanoic acid収率 90%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of 3-(5-nitropyrid-2-yl)propionic acid (4.50 g) in ethanol (140 ml) containing 10% palladium on carbon (0.45 g) was shaken under an atmosphere of hydrogen at 3.4 atmospheres pressure for 1.5 hours. The catalyst was removed by filtration and the filtrate was evaporated to dryness. The residue was recrystallised from acetonitrile to give the title compound (3.43 g) m.p. 118°-120° C.

後処理

  1. customThe catalyst was removed by filtration
  2. customthe filtrate was evaporated to dryness
  3. customThe residue was recrystallised from acetonitrile

出典と根拠

ORDレコード
ord-74ca1669f53f4947a3f1e81b6b1cd7ba
出典データセット
uspto-grants-1990_02
特許番号
US04902698

反応ノート

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