Hydrochloric Acid → (4-Methoxy-6-Methyl-2-pyriMidinyl)thiourea, 97+%

HRID 1199903ノート

反応式

HRID 1199903 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[N:6]=[C:5]([NH:10][C:11]([NH:13]NC(=O)C2C=CC=CC=2)=[S:12])[N:4]=1.[OH-].[Na+].Cl>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[N:6]=[C:5]([NH:10][C:11]([NH2:13])=[S:12])[N:4]=1

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 54321636HCID 54321636、化合物

生成物 1

HCID 939981(4-Methoxy-6-Methyl-2-pyriMidinyl)thiourea, 97+%収率 102.5%

実験手順

A mixture of 25 g of the compound from Example 3 and 55 ml of 10% aqueous sodium hydroxide was heated on the steam bath for 30 minutes, cooled, neutralized with aqueous HCl to pH 8, filtered, washed with water, dried by suction, and washed with ether to afford 16 g of the title compound, m.p. 220° d.

後処理

  1. temperaturewas heated on the steam bath for 30 minutes
  2. temperaturecooled
  3. filtrationfiltered
  4. washwashed with water
  5. customdried by suction
  6. washwashed with ether

出典と根拠

ORDレコード
ord-7c1fea8f1b2e47199d6325061a153012
出典データセット
uspto-grants-1990_02
特許番号
US04904299

反応ノート

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