Hydrochloric Acid → 5-Carboxy-2-(4,5-dihydro-2-thiazolyl)-pyridine
反応式
[Na].[C:2]([C:5]1[CH:6]=[CH:7][C:8]([C:11]#[N:12])=[N:9][CH:10]=1)([OH:4])=[O:3].N[CH2:14][CH2:15][SH:16].Cl>O.C(O)C>[C:2]([C:5]1[CH:6]=[CH:7][C:8]([C:11]2[S:16][CH2:15][CH2:14][N:12]=2)=[N:9][CH:10]=1)([OH:4])=[O:3]参加物
7
実験手順
Sodium (11 mmol) is added to a flask containing 75 ml of ethanol. As soon as the sodium has dissolved, 10 mmol of 5-carboxy-2-cyanopyridine and 11 mmol of 2-amino-ethanethiol are added and the solution is refluxed for 24 h. The solution is then diluted with 25 ml of water, made acidic (pH=5) with 2N HCl and evaporated. The residue is dissolved in 100 ml of hot chloroform, the salts are filtered off and the filtrate on cooling gives crystals of the title compound, m.p. 234°-235° C.
後処理
- temperaturethe solution is refluxed for 24 h
- customevaporated
- dissolutionThe residue is dissolved in 100 ml of hot chloroform
- filtrationthe salts are filtered off
- temperaturethe filtrate on cooling
出典と根拠
- ORDレコード
- ord-143d865299da42c986d2a696924ac583
- 出典データセット
- uspto-grants-1990_02
- 特許番号
- US04904675
反応ノート
読み込み中…