Propargyl alcohol → N-Boc-beta-alanine Propargyl Ester

HRID 12006

反応式

HRID 12006 の反応式
[C:1]([NH:8][CH2:9][CH2:10][C:11]([OH:13])=[O:12])([O:3][C:4]([CH3:7])([CH3:6])[CH3:5])=[O:2].[CH2:14](O)[C:15]#[CH:16].C1(N=C=NC2CCCCC2)CCCCC1>CCOC(C)=O>[CH2:16]([O:12][C:11](=[O:13])[CH2:10][CH2:9][NH:8][C:1]([O:3][C:4]([CH3:6])([CH3:7])[CH3:5])=[O:2])[C:15]#[CH:14]

参加物

5

反応物 3

HCID 7859Propargyl alcoholHCID 10868DicyclohexylcarbodiimideHCID 76809N-((1,1-dimethylethoxy)carbonyl)-beta-alanine

生成物 1

HCID 11831152N-Boc-beta-alanine Propargyl Ester

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

N-Boc-β-alanine (1.91 g, 10.1 mmol) and propargyl alcohol (0.675 g, 12 mmol) were dissolved in EtOAc (25 mL). Dicyclohexyl-carbodiimide (DCC, 2.06 g, 10 mmol) was added to the solution and after 16 h of stirring at room temperature, the reaction mixture was filtered and evaporated to dryness under vacuum. Crude product yield

後処理

  1. filtrationthe reaction mixture was filtered
  2. customevaporated to dryness under vacuum
  3. customCrude product yield

出典と根拠

ORDレコード
ord-71ffcbba883a4093b8e3933b35c16e12
出典データセット
uspto-grants-2010_06
特許番号
US07727713B2

関連ノート

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