Ketamine → Testosterone
反応式
CNC1(C2C=CC=CC=2Cl)C(=O)CCCC1.CC1C=CC=C(C)C=1NC1SCCCN=1.CCCCCCC([O:40][C@@H:41]1[C@@:45]2([CH3:60])[CH2:46][CH2:47][C@@H:48]3[C@:58]4([CH3:59])[C:52](=[CH:53][C:54]([CH2:56][CH2:57]4)=[O:55])[CH2:51][CH2:50][C@H:49]3[C@@H:44]2[CH2:43][CH2:42]1)=O>>[CH3:60][C@@:45]12[C@@H:41]([OH:40])[CH2:42][CH2:43][C@H:44]1[C@@H:49]1[CH2:50][CH2:51][C:52]3[C@@:58]([CH3:59])([C@H:48]1[CH2:47][CH2:46]2)[CH2:57][CH2:56][C:54](=[O:55])[CH:53]=3参加物
4
実験手順
Male AR-97Q mice and their normal littermates were castrated or sham-operated via the abdominal route under ketamine-xylazine anesthesia (50 mg/kg ketamine and 10 mg/kg xylazine, i.p.) at 4 weeks of age. Female AR-97Q mice and their littermates were subcutaneously injected 20 μg of testosterone enanthate dissolved in 20 μl of sesame oil weekly from 4 weeks of age until the end of the analysis. The control mice were given the same amount of sesame oil.
後処理
- customat 4 weeks