Tetrahydrofuran → (3-Amino-5-chloro-2-cyclopropylcarbamoyl-4-methyl-thieno[2,3-b]pyridin-6-yloxy)-acetic acid methylester

反応式

[C:1]([CH2:2][OH:3])(=[O:4])[O:5][CH3:6].[CH2:38]1[O:39][CH2:40][CH2:41][CH2:42]1.[CH3:7][Si:8]([N-:9][Si:10]([CH3:11])([CH3:12])[CH3:13])([CH3:14])[CH3:15].[CH:17]1([NH:20][C:21](=[O:22])[c:23]2[c:24]([NH2:37])[c:25]3[c:26]([n:27][c:28]([S:33]([CH3:34])=[O:35])[c:29]([Cl:32])[c:30]3[CH3:31])[s:36]2)[CH2:18][CH2:19]1.[Li+:16]>>[C:1]([CH2:2][O:3][c:28]1[n:27][c:26]2[c:25]([c:24]([NH2:37])[c:23]([C:21]([NH:20][CH:17]3[CH2:18][CH2:19]3)=[O:22])[s:36]2)[c:30]([CH3:31])[c:29]1[Cl:32])(=[O:4])[O:5][CH3:6]