1-Bromohexane → HCID 178444669、化合物

HRID 12062

反応式

HRID 12062 の反応式
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH3:7].[N:8]1[C:16]2[CH2:15][CH2:14][NH:13][CH2:12][C:11]=2[S:10][C:9]=1[NH:17][C:18]([NH2:20])=[NH:19].C(=O)([O-])[O-].[Cs+].[Cs+].[OH-].[Na+]>CN(C)C=O>[CH2:2]([N:13]1[CH2:14][CH2:15][C:16]2[N:8]=[C:9]([NH:17][C:18]([NH2:20])=[NH:19])[S:10][C:11]=2[CH2:12]1)[CH2:3][CH2:4][CH2:5][CH2:6][CH3:7]

参加物

6

反応物 4

HCID 81011-BromohexaneHCID 10796Cesium carbonateHCID 14798Sodium HydroxideHCID 178512601HCID 178512601、化合物

生成物 1

HCID 178444669HCID 178444669、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

実験手順

1-bromohexane (0.11 mmol) is added to a suspension of N-(4,5,6,7-tetrahydro-thiazolo[5,4-c]pyridine-2-yl)-guanidine (0.1 mmol) and caesium carbonate (0.22 mmol) in dimethylformamide (0.3 ml) and the reaction mixture is stirred overnight at room temperature. After adding 2M caustic soda solution (1 ml) the mixture is extracted with ethyl acetate, the combined organic phases are dried over sodium sulphate and then concentrated by evaporation, the title compound being obtained in pure form.

後処理

  1. extractionis extracted with ethyl acetate
  2. dry with materialthe combined organic phases are dried over sodium sulphate
  3. concentrationconcentrated by evaporation

出典と根拠

ORDレコード
ord-6b14da6e27204bad9338c2861405d99d
出典データセット
uspto-grants-2010_06
特許番号
US07727979B2

関連ノート

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