Hydrochloric Acid → HCID 22063467、化合物

HRID 12117ノート

反応式

HRID 12117 の反応式
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH:13]C=O)([CH3:12])[CH3:11])[CH:5]=[CH:6][C:7]=1[F:8].Cl.[OH-].[Na+]>C(O)C>[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH2:13])([CH3:11])[CH3:12])[CH:5]=[CH:6][C:7]=1[F:8]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 22063485N-[2-(3,4-Difluorophenyl)-1,1-dimethylethyl]formamide

生成物 1

HCID 22063467HCID 22063467、化合物

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

4.00 g (18.5 mmol) of N-[2-(3,4-difluorophenyl)-1,1-dimethylethyl]formamide is dissolved in ethanol, combined with concentrated hydrochloric acid, and refluxed overnight. The reaction solution is poured onto ice water, made alkaline with sodium hydroxide, and extracted with tert-butylmethyl ether. The organic phases are washed with water, dried with sodium sulfate, and evaporated down. Yellow oil. Yield: 3.2 g (92%); mass spectrometry: [M+H]+=186.

後処理

  1. temperaturerefluxed overnight
  2. additionThe reaction solution is poured onto ice water
  3. extractionextracted with tert-butylmethyl ether
  4. washThe organic phases are washed with water
  5. dry with materialdried with sodium sulfate
  6. customevaporated down

出典と根拠

ORDレコード
ord-86e31ac1b8354a41b096ba2134231c71
出典データセット
uspto-grants-2010_06
特許番号
US07727984B2

反応ノート

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