Tetrahydrofuran → 4-(4-Bromo-2-fluoro-phenylamino)-6-chloro-pyridazine-3-carboxylic acid

反応式

[Br:1][c:2]1[cH:3][c:4]([F:9])[c:5]([NH2:8])[cH:6][cH:7]1.[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[CH3:11][Si:12]([N-:13][Si:14]([CH3:15])([CH3:16])[CH3:17])([CH3:18])[CH3:19].[Cl:20][c:21]1[c:22]([C:28](=[O:29])[OH:30])[n:23][n:24][c:25]([Cl:27])[cH:26]1.[Li+:10]>>[Br:1][c:2]1[cH:3][c:4]([F:9])[c:5]([NH:8][c:21]2[c:22]([C:28](=[O:29])[OH:30])[n:23][n:24][c:25]([Cl:27])[cH:26]2)[cH:6][cH:7]1